Comparison of Recession Defects Treated with Coronally Advanced Flaps and Either Emdogain™ or Connective Tissue: 10 Years

Doctors McGuire, Scheyer and Nunn conducted a randomized, controlled, split-mouth single-center study that examined the results of nine patients with Miller Class I and II recession defects on incisors/premolars at 10 years (17 patients in original study) with baseline recession depth ≥ 4 mm with ≤ 2.5 mm keratinized tissue.

Results for both treatments showed stable, long-term clinically effective outcomes for the treatment of Miller Class I and II recession defects with improvements in the measured clinical parameters up to 10 years. Most notable was that patient satisfaction with the treatment was higher for Emdogain and two thirds of patients would choose Emdogain to avoid a secondary harvesting procedure.

So what does the science say? Emdogain + CAF showed no significant difference from CTG + CAF for measured parameters at 10 years.

McGuire MK, Scheyer ET, Nunn M. Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue: comparison of clinical parameters at 10 years. J Periodontol. 2012 Nov;83(11):1353-62.

Ten-year Results Following Treatment of Intra-bony Defects with Enamel Matrix Proteins and Guided Tissue Regeneration

Professor Anton Sculean and colleagues conducted a randomized, controlled, single center study on 56 patients to treat defects (probing depth of ≥ 6mm and intra-bony component ≥ 3mm) using 4 treatment modalities (EMD, EMD + GTR, GTR, OFD) followed by a regular maintenance program (4 visits per year) with the primary outcome a change in Clinical Attachment Level (CAL).

So what does the science say? A 10 year follow up was completed on 38 of the original 56 patients enrolled showed a significantly higher CAL gain with Straumann® Emdogain™ vs. OFD and GTR in combination with Emdogain showed no improvement over Emdogain* alone.

EMD = Straumann® Emdogain™
GTR = Guided Tissue Regeneration (membrane)
OFD = Open Flap Debridement
*In combination with periodontal surgery

Sculean A, et al. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol. 2008 Sep;35(9):817-24.