Tissue regeneration

Straumann® Emdogain supports the predictable regeneration of lost periodontal hard and soft tissue.

Regenerative treatment with Emdogain®

Periodontitis treatment involves controlling the causative bacteria and inflammation as well as subsequent regeneration of the lost periodontal hard and soft tissues in order to regain tooth attachment. The aim of regenerative treatment is the re-establishment of a full functional attachment. Emdogain® is designed to achieve this by stimulating the biological processes of natural tooth development.

The development of Emdogain® is based on a breakthrough in the knowledge of the basic biology of tooth development, enamel matrix proteins, a complex of native proteins that play a key role in the development of tooth-supporting tissues. Comprised of various proteins, which self-assemble to create this matrix, Emdogain® mediates the formation of cementum on the root of the developing tooth, providing a foundation for all necessary tissues associated with a true functional attachment. 1-5

Applying Emdogain® to the cleaned root surface of the periodontally diseased tooth helps to regenerate the periodontium, which includes the cementum, periodontal ligament and alveolar bone.1-5

Effects at the cellular level

Emdogain® forms an insoluble three dimensional extra-cellular matrix. This matrix remains on the root surface for 2-4 weeks and allows for the selective colonization, proliferation and differentiation of cells.6 

1. When Straumann® Emdogain is applied the enamel matrix derived proteins precipitate on the root surface to form a matrix layer.

4. Supporting cells are attracted and differentiate into cementoblasts which start with the formation of the cement matrix in which the periodontal fibres will be fixed.

2. The matrix stimulates the attraction and proliferation of mesenchymal cells from the healthy part of the periodontium.

5. The newly formed cement layer increases in thicknes,s extending the periodontal ligament.

3. The cells secrete natural and specific cytokines and autokrine substances promoting the necessary proliferation.

6. Within months, the defect fills with newly formed periodontal ligament. As the periodontal ligament is formed, new bone continues to develop.


Emdogain® is indicated for:

  • Intrabony defects
  • Furcation defects
  • Wide intrabony defects
  • Recession defects

In wide defects or where additional soft tissue support is needed, we recommend usage of Emdogain® in combination with BoneCeramic™.

Emdogain® PLUs

Emdogain® and BoneCeramic™  are also available in combination as Emdogain® PLUS.

Emdogain® PLUS also includes PrefGel®, a pH neutral, 24 % EDTA root surface conditioner intended to offer an effective, yet gentle removal of the "smear layer" during periodontal surgery.

1 Pimentel SP, et al. Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs. J Clin Periodontol. 2006;33:900-907.
Dieter D. Bosshardt et al. Effects of enamel matrix proteins on tissue formation along the roots of human teeth. J Periodontal Res. 2005;40:158-167.
Sallum EA et al. Enamel Matrix Derivative and Guided Tissue Regeneration in the Treatment of Dehiscence-Type Defects: A Histomorphometric Study in Dogs J Periodontol. 2004;75:1357-1363.
Sakallioglu U et al. Healing of periodontal defects treated with enamel matrix proteins and root surface conditioning - an experimental study in dogs Biomaterials. 2004;25:1831-1840.
Cochran DL et al. The effect of enamel matrix proteins on periodontal regeneration as determined by histological analyses. J Periodontol. 2003;74:1043-1055.
Stratul S, Rusu D, Sculean A. The use of an enamel matrix protein derivative (Emdogain) in regenerative periodontal therapy. Which applications are evidence based? Part III. Results from human histological studies. Timisoara Medical Journal 2008;58:108-110.